Resposta neural subcortical aos estímulos clique e de fala em lactentes e crianças pequenas com citomegalovírus congênito: um estudo preliminar
Subcortical neural response to click and speech stimuli in infants and young children with congenital cytomegalovirus: a preliminary study
Ketilly Samilly de Souza Silva; Josefa Viviane de Moura Ferreira; Lara Louíse Pinto Câmara; Mylena Taise Azevedo Lima Bezerra; Sheila Andreoli Balen
Resumo
Objetivo: Analisar a resposta neural da via subcortical por meio de estímulos clique e de fala em lactentes e crianças pequenas com citomegalovírus congênito (CMVc). Método: Estudo transversal e prospectivo. A amostra foi constituída por lactentes e crianças pequenas com mediana na idade de 6,43 meses (Q1–Q3: 2,62–11,25) no grupo CMVc (G1; n=10) e de 6,23 meses (Q1–Q3: 1,60–12,06) no grupo controle (G2; n=10). Todos os participantes apresentaram Emissões Otoacústicas Evocadas por Estímulo Transiente (EOAT) e timpanometria com pico de pressão positiva bilateralmente. Os procedimentos incluíram anamnese, Potencial Evocado Auditivo de Tronco Encefálico com estímulo clique (PEATE-clique) e Frequency Following Response (FFR). O PEATE-clique foi realizado nas intensidades de 80 e 30 dB nNA, em ambas as orelhas. O FFR foi registrado na orelha direita com estímulo de fala /da/ de 170 ms. As respostas do FFR foram analisadas nos domínios temporal e espectral, quanto à sincronia neural, representação espectral e estabilidade da resposta à fala. Foi aplicado o teste de Mann-Whitney ou Teste t de Student para análise intergrupos. O teste Wilcoxon foi aplicado na análise intragrupos. Resultados: Na análise das latências e amplitudes do PEATE-clique, bem como nas medidas do FFR relacionadas à codificação neural subcortical da fala, não foram observadas diferenças estatisticamente significativas entre os grupos e entre as orelhas na análise intergrupos. Conclusão: Os resultados preliminares indicam padrão semelhante de codificação neural subcortical da fala e de sincronia neural em lactentes e crianças pequenas com e sem CMVc.
Palavras-chave
Abstract
Purpose: To analyze the neural response of the subcortical pathway through click and speech stimuli in infants and young children with congenital cytomegalovirus (CMVc). Methods: Cross-sectional and prospective study. The sample consisted of infants and young children with a median age of 6.43 months (Q1–Q3: 2.62–11.25) in the CMV group (G1; n=10) and 6.23 months (Q1–Q3: 1.60–12.06) in the control group (G2; n=10). All participants underwent Transient Evoked Otoacoustic Emissions (TEOAE) and bilateral peak positive pressure tympanometry. The procedures included anamnesis, Auditory Brainstem Response with click stimulus (ABR-click), and Frequency Following Response (FFR). Click ABR was performed at intensities of 80 and 30 dB nHL in both ears. FFR was recorded in the right ear with a speech stimulus /da/ of 170 ms. FFR responses were analyzed in the temporal and spectral domains, regarding neural synchrony, spectral representation, and stability of the speech response. The Mann-Whitney test or Student’s t-test was applied for intergroup analysis. The Wilcoxon test was applied for intragroup analysis. Results: In the analysis of click ABR latencies and amplitudes, as well as in FFR measurements related to subcortical neural coding of speech, no statistically significant differences were observed between groups or between ears in the intergroup analysis. Conclusion: Preliminary results indicate a similar pattern of subcortical neural coding of speech and neural synchrony in infants and young children with and without CMVc.
Keywords
References
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Submitted date:
07/08/2025
Accepted date:
03/04/2026
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