Efeitos da fotobiomodulação associada à reabilitação vestibular no tratamento de pacientes com sintomas vestibulares e zumbido: ensaio clínico randomizado triplo-cego
Effects of photobiomodulation associated with vestibular rehabilitation in the treatment of patients with vestibular symptoms and tinnitus: a triple-blind randomized clinical trial
Thales Roges Vanderlei de Góes; Marine Raquel Diniz da Rosa; Giorvan Anderson dos Santos Alves; Rafael Nóbrega Bandeira; Sávio Bastos
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1 Newman-Toker DE, Cannon LM, Stofferahn ME, Rothman RE, Hsieh YH, Zee DS. Imprecision in patient reports of dizziness symptom quality: a cross-sectional study conducted in an acute care setting. Mayo Clin Proc. 2007;82(11):1329-40.
2 Lee MY, Hyun JH, Suh MW, Ahn JC, Chung PS, Jung JY. Treatment of peripheral vestibular dysfunction using photobiomodulation. J Biomed Opt. 2017;22(8):085001.
3 Lin E, Aligene K. Pharmacology of balance and dizziness. NeuroRehabilitation. 2013;32(3):529-42.
4 Hall CD, Herdman SJ, Whitney SL, Anson ER, Carender WJ, Hoppes CW, et al. Vestibular rehabilitation for peripheral vestibular hypofunction: an updated clinical practice guideline from the Academy of Neurologic Physical Therapy of the American Physical Therapy Association. J Neurol Phys Ther. 2022;46(2):118-77.
5 Tepel M. N-Acetylcysteine in the prevention of ototoxicity. Kidney Int. 2007;72(3):231-2.
6 Dunlap PM, Holmberg JM, Whitney SL. Vestibular rehabilitation: advances in peripheral and central vestibular disorders. Curr Opin Neurol. 2019;32(1):137-44.
7 Yan T, Zong F, Han X, Wang X, Li Q, Qiao R, et al. Vestibular neuritis in patients among different age groups: clinical features and outcomes. J Am Acad Audiol. 2020;31(9):629-35.
8 McDonnell MN, Hillier SL. Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database Syst Rev. 2015;2015(1):CD005397.
9 Hidayati HB, Imania HAN, Octaviana DS, Kurniawan RB, Wungu CDK, Ariarini NN, et al. Vestibular rehabilitation therapy and corticosteroids for vestibular neuritis: a systematic review and meta-analysis of randomized controlled trials. Medicina. 2022;58(9):1221.
10 Esmaili AA, Renton J. A review of tinnitus. Aust J Gen Pract. 2018;47(4):205-8.
11 Jarach CM, Lugo A, Scala M, Van Den Brandt PA, Cederroth CR, Odone A, et al. Global prevalence and incidence of tinnitus: a systematic review and meta-analysis. JAMA Neurol. 2022;79(9):888-900.
12 Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res. 2005;48(5):1204-35.
13 Vieira PP, Marchori LLM, Melo JJ. Estudo da possível associação entre zumbido e vertigem. Rev CEFAC. 2010;12(4):641-5.
14 Dias A, Cordeiro R, Corrente JE. Incômodo causado pelo zumbido medido pelo Questionário de Gravidade do Zumbido. Rev Saude Publica. 2006;40(4):706-11.
15 García A, Madrigal J, Castillo M. Vestibular migraine and tinnitus: a challenging narrative. Cureus. 2021;13(6):e15998.
16 Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, et al. Clinical practice guideline: ménière’s disease. Otolaryngol Head Neck Surg. 2020;162(2, Suppl):S1-55.
17 Doan SN, Stagner JP, Chu CH, Johnson NM, Hall JW 3rd, Dias JW. Listening difficulties in children with normal audiograms: relation to hearing and cognition. Front Neurol. 2023;14:1301221.
18 Doan SN, Stagner JP, Chu CH, Johnson NM, Hall JW 3rd, Dias JW. Listening difficulties in children with normal audiograms: relation to hearing and cognition. Front Neurol. 2023;14:1301221.
19 Talluri S, Palaparthi SM, Michelogiannakis D, Khan J. Efficacy of photobiomodulation in the management of tinnitus: a systematic review of randomized control trials. Eur Ann Otorhinolaryngol Head Neck Dis. 2022;139(2):83-90.
20 Lee JH, Kim S, Jung JY, Lee MY. Applications of photobiomodulation in hearing research: from bench to clinic. Biomed Eng Lett. 2019;9(3):351-8.
21 Lee MY, Hyun JH, Suh MW, Ahn JC, Chung PS, Jung JY. Treatment of peripheral vestibular dysfunction using photobiomodulation. J Biomed Opt. 2017;22(8):1-7.
22 SBFa: Sociedade Brasileira de Fonoaudiologia. Sociedade Brasileira de Audiologia. Guia de orientação na avaliação audiológica: volume I – audiometria tonal liminar, logoaudiometria e medidas de imitância acústica. Brasília: Sistema de Conselhos de Fonoaudiologia; 2020.
23 Cleveland Clinic. Cleveland Clinic Risk Calculator Library [Internet]. 2025 [citado em 2025 Mar 11]. Disponível em:
24 Ferreira PEA, Cunha F, Onishi ET, Branco-Barreiro FCA, Ganança FF. Tinnitus handicap inventory: adaptação cultural para o Português brasileiro. Braz J Otorhinolaryngol. 2005;17(3):303-10.
25 Castro ASO, Gazzola JM, Natour J, Ganança FF. Versão brasileira do Dizziness Handicap Inventory. Braz J Otorhinolaryngol. 2007;19(1):97-104.
26 Figueiredo RR, Azevedo AA, Oliveira PM. Correlation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients. Braz J Otorhinolaryngol. 2009;75(1):76-9.
27 Michel L, Laurent T, Alain T. Rehabilitation of dynamic visual acuity in patients with unilateral vestibular hypofunction: earlier is better. Eur Arch Oto-Rhino-Laryngol. 2020;277(1):103-13.
28 Cordero-Civantos C, Calle-Cabanillas MI, Álvarez-Gómez L. Rehabilitación vestibular con posturografía dinámica. Rev ORL. 2019;11(1):89-95.
29 Morozetti PG, Ganança CF, Chiari BM. Comparação de diferentes protocolos de reabilitação vestibular em pacientes com disfunções vestibulares periféricas. J Soc Bras Fonoaudiol. 2011;23(1):44-50.
30 Gavalas GJ, Passou EM, Vathilakis JM. Tinnitus of vestibular origin. Scand Audiol Suppl. 2001;30(1):185-6.
31 Tokle G, Mørkved S, Bråthen G, Goplen FK, Salvesen Ø, Arnesen H, et al. Efficacy of vestibular rehabilitation following acute vestibular neuritis: a randomized controlled trial. Otol Neurotol. 2020;41(1):78-85.
32 Kadan İ, Kirazlı G, Öğüt MF, Kirazlı T. Evaluation of vestibulo-ocular reflex (Vor) in tinnitus patients with normal hearing. J Int Adv Otol. 2021;17(1):13-8.
33 Caspary DM, Hughes LF, Ling LL. Age-related GABAA receptor changes in rat auditory cortex. Neurobiol Aging. 2013;34(5):1486-96.
34 Bu J, Sathyendra V, Nagykery N, Geula C. Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex. Exp Neurol. 2003;182(1):220-31.
35 Yang T, Hu N, Pangršič T, Green S, Hansen M, Lee A. Functions of CaBP1 and CaBP2 in the peripheral auditory system. Hear Res. 2018;364:48-58.
36 Bathini M, Raghushaker CR, Mahato KK. The molecular mechanisms of action of photobiomodulation against neurodegenerative diseases: a systematic review. Cell Mol Neurobiol. 2022;42(4):955-71.
37 Mollasadeghi A, Mirmohammadi SJ, Mehrparvar AH, Davari MH, Shokouh P, Mostaghaci M, et al. Efficacy of low-level laser therapy in the management of tinnitus due to noise-induced hearing loss: a double-blind randomized clinical trial. ScientificWorldJournal. 2013;2013(1):596076.
38 Choi JE, Lee MY, Chung PS, Jung JY. A preliminary study on the efficacy and safety of low-level light therapy in the management of cochlear tinnitus: a single blind randomized clinical trial. Int Tinnitus J. 2019;23(1):52-7.
39 Panhóca VH, Aquino AE Jr, Souza VB, Ferreira SA, Ferreira LT, Oliveira Souza KJ, et al. Effects of red and infrared laser therapy in patients with tinnitus: a double-blind, clinical, randomized controlled study combining light with ultrasound, drugs and vacuum therapy. J Pers Med. 2023;13(4):581.
40 Rhee CK, Lim ES, Kim YS, Chung YW, Jung JY, Chung PS. Effect of low level laser (LLL) on cochlear and vestibular inner ear including tinnitus. In: Photonic Therapeutics and Diagnostics II; 2006; San Jose, CA, USA. Proceedings. Bellingham: SPIE; 2006.
41 Elsayad OA, Alsharif B. Low-level laser therapy for treatment of tinnitus in Red Sea scuba divers: a randomized clinical study. Egypt J Otolaryngol. 2022;38(1):4.
42 Silva MR, Scheffer AR, de Assunção Bastos RS, Chavantes MC, Mondelli MFCG. The effects of photobiomodulation therapy in individuals with tinnitus and without hearing loss. Lasers Med Sci. 2022;37(9):3485-94.
43 Dehkordi MA, Einolghozati S, Ghasemi SM, Abolbashari S, Meshkat M, Behzad H. Effect of low-level laser therapy in the treatment of cochlear tinnitus: a double-blind, placebo-controlled study. Ear Nose Throat J. 2015;94(1):32-6. PMid:25606834.
44 Goodman SS, Bentler RA, Dittberner A, Mertes IB. The effect of low-level laser therapy on hearing. ISRN Otolaryngol. 2013;2013:916370.
45 Teggi R, Bellini C, Piccioni LO, Palonta F, Bussi M. Transmeatal low-level laser therapy for chronic tinnitus with cochlear dysfunction. Audiol Neurootol. 2009;14(2):115-20.
46 Fernández-Nava MJ, Ferreira Cendón S, Alonso de la Iglesia S, Cecilio-Rivas MM, Alonso San Eloy AB, Batuecas Caletrío A. Límites de estabilidad en los distintos patrones posturográficos: estudio de cohortes. Rev ORL. 2022;13(4):e28981.
Submetido em:
11/03/2025
Aceito em:
06/06/2025
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