Did the speech of patients with Myasthenia Gravis decline over 4 years?

Annelise Ayres; Marina Martins Pereira Padovani; Maira Rozenfeld Olchik; Maiara Laís Mallmann Kieling; Vanessa Brzoskowski dos Santos; Rui Rothe-Neves; Mara Behlau

doi:10.1590/2317-1782/20232023055en

Original Article

Did the speech of patients with Myasthenia Gravis decline over 4 years?

Annelise Ayres; Marina Martins Pereira Padovani; Maira Rozenfeld Olchik; Maiara Laís Mallmann Kieling; Vanessa Brzoskowski dos Santos; Rui Rothe-Neves; Mara Behlau

http://dx.doi.org/10.1590/2317-1782/20232023055en CoDAS, vol.36, n2, e20230055, 2024

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Abstract

ABSTRACT: Purpose: To compare the speech and voice patterns of myasthenia gravis (MG) patients over four years, and correlate the results with clinical aspects of the disease.

Methods: Data was collected for 4 years. The clinical assessment tools included the Quantitative Myasthenia Gravis (QMG) score, the Myasthenia Gravis Foundation of America (MGFA) clinical classification, and the Myasthenia Gravis Quality of Life 15-item Scale (MG-QoL). To assess speech, the recorded speaking tasks were analyzed acoustically and given auditory-perceptual ratings. Sex (equal distribution) and age (p=0.949) were used as matching criteria in the final sample, which consisted of 10 individuals in the MG group (MGG) and 10 individuals in the control group (CG).

Results: After 4 years, the MG participants presented stable health status, increased mild and moderate dysarthria (from 40% to 90% of the subjects), and a significant deterioration in the respiration, phonation, and articulation subsystems. The acoustic analysis showed a decline in articulatory patterns (speech rate p=0.047, articulation rate p=0.007, mean syllable duration p=0.007) and vocal quality (increased jitter p=0.022). In the follow-up comparison, there was a significant difference between the phonation variables (shimmer and harmonic-to-noise ratio) of the MGG and CG.

Conclusion: The MG patients presented a decline in speech over four years and an increase in mild and moderate dysarthria. Despite presenting stable health status, their respiratory, phonatory, and articulatory subsystems worsened. There was no correlation between speech patterns and clinical characteristics of the disease (severity and motor scale).

Keywords

Speech, Voice, Dysarthria, Speech Acoustics, Myasthenia Gravis

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Submitted date:
03/27/2023

Accepted date:
05/31/2023

Did the speech of patients with Myasthenia Gravis decline over 4 years?

Annelise Ayres; Marina Martins Pereira Padovani; Maira Rozenfeld Olchik; Maiara Laís Mallmann Kieling; Vanessa Brzoskowski dos Santos; Rui Rothe-Neves; Mara Behlau

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