What are the barriers to participation in a neuromodulation pilot trial for aphasia after stroke?
Mariana Lopes Andreoli; Juli Thomaz de Souza; Priscila Watson Ribeiro; Rafael Dalle Molle da Costa; Taís Regina da Silva; Fernanda Cristina Winckler; Gabriel Pinheiro Modolo; Karen Fernanda Alves; Pedro Tadao Hamamoto Filho; Rafael Delascio Garcia; Luiz Eduardo Gomes Garcia Betting; Silmeia Garcia Zanati Bazan; Rodrigo Bazan; Gustavo José Luvizutto
Abstract
Purpose: Aphasia is a common and debilitating manifestation of stroke. Transcranial electrical stimulation uses low-intensity electric currents to induce changes in neuronal activity. Recent evidence suggests that noninvasive techniques can be a valuable rehabilitation tool for patients with aphasia. However, it is difficult to recruit patients with aphasia for trials, and the reasons for this are not well understood. This study aimed to elucidate the main difficulties involved in patient’s recruitment and inclusion in a randomized clinical study of neuromodulation in aphasia. Methods: We evaluated the reasons for the exclusion of patients in a pilot, randomized, double-blinded clinical trial in which patients diagnosed with motor aphasia after stroke were recruited from March to November 2018. A descriptive statistical analysis was performed. Results: Only 12.9% (4) of patients with ischemic stroke were included in the clinical trial. A total of 87.1% (27) of the 31 recruited patients were excluded for various reasons including: sensory aphasia (32.2%), dysarthria (25.8%), spontaneous clinical recovery (16.1%), previous stroke (6.4%), and death or mutism (3.2%). Conclusion: The presence of other types of aphasia, dysarthria, spontaneous recovery, deaths, and mutism were barriers to recruiting patients evidenced in this neuromodulation study
Keywords
References
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Submitted date:
02/06/2020
Accepted date:
08/13/2020
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